Resistomycin (Synonyms: Antibiotic A-3733A,Heliomycin) |
Catalog No.GC13832
One-Click Copy Product Info
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La resistomicina, un antibiÓtico poliquétido pentacÍclico, posee actividad anticancerÍgena e induce la apoptosis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 20004-62-0
Sample solution is provided at 25 µL, 10mM.
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Resistomycin is a natural antibiotic.
Resistomycin is a natural antibiotic produced by several actinobacteriae, such as Streptomyces.
In vitro: Resistomycin, a tetrahydroxyanthrone derivative, was isolated from the culture broth of Streptomyces sulphureus and a similar polyphenolic dianthraquinone, hypericin, was isolated from an extract of Hypericum perforatum L. as modulators for apoptosis. In human megakaryoblastic leukemia CMK-7 cells, resistomycin could inhibit apoptosis induced by actinomycin D (AD) with or without acceleration by colcemid (CL), IC50 for inhibition against AD-induced apoptosis was about 0.5 μM and IC50 for inhibition against AD plus CL-induced apoptosis was about 1 μM. CL alone induced weak apoptosis in cells, which could be enhanced by resistomycin. Moreover, it was found that both hypericin and resistomycin were able to scavenge superoxide anion radicals at the same rate as luteolin. In addition, PKC in CMK-7 cells could be inhibited by hypericin and luteolin, but not obviously inhibited by resistomycin [1].
In vivo: Up to now, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Shiono, Y. ,Shiono, N.,Seo, S., et al. Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line. Z. Naturforsch. C. 57(9-10), 923-929 (2002).
| Cas No. | 20004-62-0 | SDF | |
| Sinónimos | Antibiotic A-3733A,Heliomycin | ||
| Chemical Name | 3,5,7,10-tetrahydroxy-1,1,9-trimethyl-2H-benzo[cf]pyrene-2,6(1H)-dione | ||
| Canonical SMILES | O=C1C(C)(C)C2=C3C4=C(C(O)=CC(C)=C4C(O)=C2)C(C5=C(O)C=C(O)C1=C53)=O | ||
| Formula | C22H16O6 | M.Wt | 376.4 |
| Solubility | Soluble in DMSO;dimethyl formamide | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6567 mL | 13.2837 mL | 26.5675 mL |
| 5 mM | 531.3 μL | 2.6567 mL | 5.3135 mL |
| 10 mM | 265.7 μL | 1.3284 mL | 2.6567 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)