Tesirine (Synonyms: SG3249) |
| Catalog No.GC63216 |
Tesirina (SG3249) es un conjugado anticuerpo-fármaco (ADC) con carga de dímero de pirrolobenzodiazepina (PBD). Tesirine combina una potente actividad antitumoral con propiedades fisicoquímicas deseables, como una hidrofobicidad favorable y características mejoradas de conjugación. SG3199 es el componente liberado de la cabeza de guerra del ADC Tesirine. SG3199 retiene una actividad picomolar en un panel de líneas celulares cancerosas. Los dímeros PBD son agentes altamente eficientes para entrecruzar el surco menor del ADN con citotoxicidad potente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1595275-62-9
Sample solution is provided at 25 µL, 10mM.
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Tesirine (SG3249) is a drug-linker conjugates for ADC which is used in the treatment of several cancers. PBD Dimer is a DNA alkylating which inhibits DNA replication[1].
[1]. Samantha Congreve, et al. Antibody drug conjugates (ADC) Current status and mapping of ADC:s in clinical programs. Uppsala Universitet.
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