VU 0238429 (Synonyms: HY-12157, ML129) |
| Catalog No.GC15990 |
VU 0238429 es un modulador alostérico positivo del receptor muscarÍnico de acetilcolina subtipo 5 (mAChR5 o M5), con una CE50 de 1,16 μM.
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Cas No.: 1160247-92-6
Sample solution is provided at 25 µL, 10mM.
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VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM.
VU 0238429 is positive allosteric modulator of mAChR5 (M5), with an EC50 of 1.16 μM, >30-fold selectivity versus M1 and M3, with no M2 or M4 potentiator activity[1].
References:
[1]. Bridges TM, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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