VV116 (Synonyms: JT001) |
| Catalog No.GC64800 |
VV116 (JT001) es un agente antiviral nucleÓsido activo por vÍa oral contra el SARS-CoV-2 y la infecciÓn por el virus respiratorio sincitial (RSV).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2779498-79-0
Sample solution is provided at 25 µL, 10mM.
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VV116 (JT001) is an orally active nucleoside antiviral agent against SARS-CoV-2 and respiratory syncytial virus (RSV) infection. VV116 has favorable oral bioavailability, excellent in vitro antiviral activity and selectivity[1][2].
VV116 (0-1000 μM; 48 hours) can inhibit RSV replication in A549 cells[1].
VV116 (25, 50 and 100 mg/kg; PO; b.i.d for 4 days) exhibits a stronger activity and decreases the virus titers below the detection limit at 50 mg/kg, also reduces lung injury after RSV infection[1].VV116 (25, 50 and 100 mg/kg; PO; single dosage) exhibits favorable PK properties and good safety profile[1].Pharmacokinetic Parameters of VV116 (JT001) in Balb/c mice[1]. PO (25 mg/kg) PO (50 mg/kg) PO (100 mg/kg) Tmax (h)0.42 ± 0.140.42 ± 0.140.42 ± 0.14Cmax (ng/mL)5360 ± 56011617 ± 344324017 ± 6521AUC0-t (ng/mL.h)11461 ± 101324594 ± 105947799 ± 6545 AUC0-∞ (ng/mL.h)11534 ± 99224739 ± 102848014 ± 6696MRT0-∞ (ng/mL.h)2.25 ± 0.322.15 ± 0.262.28 ± 0.53Tmax (h)2.30 ± 1.103.27 ± 1.924.25 ± 0.53
[1]. Zhang R, et al. Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model. Signal Transduct Target Ther. 2022;7(1):123. Published 2022 Apr 16.
[2]. Qian HJ, et al. Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects [published online ahead of print, 2022 Mar 16]. Acta Pharmacol Sin. 2022;1-9.
| Cas No. | 2779498-79-0 | SDF | |
| Sinónimos | JT001 | ||
| Formula | C24H31DBrN5O7 | M.Wt | 583.45 |
| Solubility | DMSO : 250 mg/mL (428.49 mM; Need ultrasonic) | Storage | 4°C, away from moisture |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.7139 mL | 8.5697 mL | 17.1394 mL |
| 5 mM | 0.3428 mL | 1.7139 mL | 3.4279 mL |
| 10 mM | 0.1714 mL | 0.857 mL | 1.7139 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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