1,2-Distearoyl-sn-glycero-3-PC (Synonyms: Coatsome MC 8080, 1,2-Distearoyl-sn-glycero-3-Phosphocholine, 1,2-DSPC)

1,2-Distearoyl-sn-glycero-3-PC (DSPC) is a lipid that can be used to synthesize liposomes, micelles and other types of artificial membranes^[1]. 1,2-Distaroyl-sn-glycero-3-PC is a metabolite produced in Saccharomyces cerevisiae^[2]. Mixed lipid monolayers containing 1,2-Distearoyl-sn-glycero-3-PC can bind to calcium-mediated DNA^[3].

1,2-Distearoyl-sn-glycero-3-PC and CdSe/ZnS QD were prepared into liposome formulations to encapsulate the drug TNT, and were treated with HeLa cells. Compared with free TNT, it was easier to be taken up and internalized by cells, significantly improving Cytotoxic effects^[4]. 1,2-Distaroyl-sn-glycero-3-PC encapsulated liposomes treated HeLa and 104C1 cells to promote Chlamydia trachomatis Ct D infection^[5].

References:

[1] Caldo K M P, Shen W, Xu Y, et al. Diacylglycerol acyltransferase 1 is activated by phosphatidate and inhibited by SnRK1‐catalyzed phosphorylation[J]. The Plant Journal, 2018, 96(2): 287-299.

[2] de Kroon A I P M. Metabolism of phosphatidylcholine and its implications for lipid acyl chain composition in Saccharomyces cerevisiae[J]. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2007, 1771(3): 343-352.

[3] Dabkowska A P, Barlow D J, Clifton L A, et al. Calcium-mediated binding of DNA to 1, 2-distearoyl-sn-glycero-3-phosphocholine-containing mixed lipid monolayers[J]. Soft matter, 2014, 10(11): 1685-1695.

[4] Seleci M, Ag Seleci D, Scheper T, et al. Theranostic liposome–nanoparticle hybrids for drug delivery and bioimaging[J]. International journal of molecular sciences, 2017, 18(7): 1415.

[5] Wali S, Gupta R, Yu J J, et al. Guinea pig genital tract lipidome reveals in vivo and in vitro regulation of phosphatidylcholine 16: 0/18: 1 and contribution to Chlamydia trachomatis serovar D infectivity[J]. Metabolomics, 2016, 12: 1-11.