1,2-Distearoyl-sn-glycero-3-PC (Synonyms: Coatsome MC 8080, 1,2-Distearoyl-sn-glycero-3-Phosphocholine, 1,2-DSPC) |
| Catalog No.GC41832 |
1,2-Distearoyl-sn-glycero-3-PC (DSPC) is a lipid that can be used to synthesize liposomes, micelles and other types of artificial membranes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 816-94-4
Sample solution is provided at 25 µL, 10mM.
1,2-Distearoyl-sn-glycero-3-PC (DSPC) is a lipid that can be used to synthesize liposomes, micelles and other types of artificial membranes[1]. 1,2-Distaroyl-sn-glycero-3-PC is a metabolite produced in Saccharomyces cerevisiae[2]. Mixed lipid monolayers containing 1,2-Distearoyl-sn-glycero-3-PC can bind to calcium-mediated DNA[3].
1,2-Distearoyl-sn-glycero-3-PC and CdSe/ZnS QD were prepared into liposome formulations to encapsulate the drug TNT, and were treated with HeLa cells. Compared with free TNT, it was easier to be taken up and internalized by cells, significantly improving Cytotoxic effects[4]. 1,2-Distaroyl-sn-glycero-3-PC encapsulated liposomes treated HeLa and 104C1 cells to promote Chlamydia trachomatis Ct D infection[5].
References:
[1] Caldo K M P, Shen W, Xu Y, et al. Diacylglycerol acyltransferase 1 is activated by phosphatidate and inhibited by SnRK1‐catalyzed phosphorylation[J]. The Plant Journal, 2018, 96(2): 287-299.
[2] de Kroon A I P M. Metabolism of phosphatidylcholine and its implications for lipid acyl chain composition in Saccharomyces cerevisiae[J]. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2007, 1771(3): 343-352.
[3] Dabkowska A P, Barlow D J, Clifton L A, et al. Calcium-mediated binding of DNA to 1, 2-distearoyl-sn-glycero-3-phosphocholine-containing mixed lipid monolayers[J]. Soft matter, 2014, 10(11): 1685-1695.
[4] Seleci M, Ag Seleci D, Scheper T, et al. Theranostic liposome–nanoparticle hybrids for drug delivery and bioimaging[J]. International journal of molecular sciences, 2017, 18(7): 1415.
[5] Wali S, Gupta R, Yu J J, et al. Guinea pig genital tract lipidome reveals in vivo and in vitro regulation of phosphatidylcholine 16: 0/18: 1 and contribution to Chlamydia trachomatis serovar D infectivity[J]. Metabolomics, 2016, 12: 1-11.
| Cas No. | 816-94-4 | SDF | |
| Synonyms | Coatsome MC 8080, 1,2-Distearoyl-sn-glycero-3-Phosphocholine, 1,2-DSPC | ||
| Canonical SMILES | O=C(CCCCCCCCCCCCCCCCC)OC[C@@H](OC(CCCCCCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O | ||
| Formula | C44H88NO8P | M.Wt | 790.2 |
| Solubility | ≤25mg/ml in ethanol | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.2655 mL | 6.3275 mL | 12.655 mL |
| 5 mM | 0.2531 mL | 1.2655 mL | 2.531 mL |
| 10 mM | 0.1266 mL | 0.6328 mL | 1.2655 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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