1G244 |
| رقم الكتالوجGC39296 |
1G244 هو مثبط قوي DPP8 / 9 مع IC50s من 12 نانومتر و 84 نانومتر ، على التوالي1G244 لا يمنع DPPIV و DPPIIيستحث 1G244 موت الخلايا المبرمج في خلايا المايلوما المتعددة وله تأثيرات مضادة للورم النخاعي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 847928-32-9
Sample solution is provided at 25 µL, 10mM.
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1G244 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects[1][2].
[1]. Sato T, et al. DPP8 is a novel therapeutic target for multiple myeloma. Sci Rep. 2019 Dec 2;9(1):18094. [2]. Leen Heirbaut, et al. Probing for improved selectivity with dipeptidederived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation. MedChemComm. 2016, 7.
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