(1R,2R)-2-PCCA(hydrochloride) |
| رقم الكتالوجGC30855 |
(1R ، 2R) -2-PCCA (هيدروكلوريد) عبارة عن دياستيريومير من 2-PCCA ، ويعمل بمثابة ناهض قوي لمستقبلات GPR88 ، مع EC50 من 3 نانومتر في الفحص الخالي من الخلايا ، و 603 نانومتر في فحص الخلية.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1609563-71-4
Sample solution is provided at 25 µL, 10mM.
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(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM.
(1R,2R)-2-PCCA hydrochloride is a potent GPR88 receptor agonist, with an EC50 of 3 nM[1]. (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC50 of 56 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct[2].
[1]. Bi, Yingzhi, et al. Modulators of G Protein-Coupled Receptor 88. US 20110251204 A1. [2]. Jin C, et al. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432.
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