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(1R,2R)-2-PCCA(hydrochloride)

カタログ番号GC30855

(1R,2R)-2-PCCA(塩酸塩) は 2-PCCA のジアステレオマーであり、強力な GPR88 受容体アゴニストとして作用し、無細胞アッセイで 3 nM、細胞アッセイで 603 nM の EC50 を示します。

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(1R,2R)-2-PCCA(hydrochloride) 化学構造

Cas No.: 1609563-71-4

サイズ 価格 在庫数 個数
10mM (in 1mL DMSO)
$270.00
在庫あり
5mg
$232.00
在庫あり
10mg
$417.00
在庫あり
25mg
$834.00
在庫あり
50mg
$1,298.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM.

(1R,2R)-2-PCCA hydrochloride is a potent GPR88 receptor agonist, with an EC50 of 3 nM[1]. (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC50 of 56 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct[2].

[1]. Bi, Yingzhi, et al. Modulators of G Protein-Coupled Receptor 88. US 20110251204 A1. [2]. Jin C, et al. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432.

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