الصفحة الرئيسية>>Signaling Pathways>> Cell Cycle/Checkpoint>> G2/M>>2,3-Dimethoxy-5-methyl-p-benzoquinone

2,3-Dimethoxy-5-methyl-p-benzoquinone (Synonyms: Coenzyme Q0, CoQ0)

رقم الكتالوجGC40947

2،3-Dimethoxy-5-methyl-p-benzoquinone (CoQ0) هو مركب يوبيكوينون فعال عن طريق الفم يمكن اشتقاقه من Antrodia cinnamomea.

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2,3-Dimethoxy-5-methyl-p-benzoquinone التركيب الكيميائي

Cas No.: 605-94-7

الحجم السعر المخزون الكميّة
1g
38٫00
متوفر
5g
171٫00
متوفر
10g
302٫00
متوفر
25g
662٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of 2,3-Dimethoxy-5-methyl-p-benzoquinone

2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E. It inhibits the growth of SKOV-3, A2780, and A2870/CP70 human ovarian carcinoma cells (IC50s = 26.6, 27.3, and 28.4 µM, respectively) with a cytotoxic concentration of greater than 40 µM for non-cancerous ovarian surface epithelial cells. It halts the cell cycle at the G2/M phase, increases the production of reactive oxygen species (ROS), and induces autophagy and apoptosis in SKOV-3 cells. 2,3-Dimethoxy-5-methyl-p-benzoquinone downregulates the protooncogene HER-2 and decreases the protein levels of phosphorylated AKT and mTOR in SKOV-3 cells. It also decreases the incidence of tumors and tumor burden in a SKOV-3 human ovarian carcinoma mouse xenograft model when administered at a dose of 2.5 mg/kg every four days.

Chemical Properties of 2,3-Dimethoxy-5-methyl-p-benzoquinone

Cas No. 605-94-7 SDF
المرادفات Coenzyme Q0, CoQ0
Canonical SMILES O=C(C(C)=C1)C(OC)=C(OC)C1=O
Formula C9H10O4 M.Wt 182.2
الذوبان DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 0.2 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 2,3-Dimethoxy-5-methyl-p-benzoquinone

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 5.4885 mL 27.4424 mL 54.8847 mL
5 mM 1.0977 mL 5.4885 mL 10.9769 mL
10 mM 0.5488 mL 2.7442 mL 5.4885 mL
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In vivo Formulation Calculator (Clear solution) of 2,3-Dimethoxy-5-methyl-p-benzoquinone

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Average Rating: 5 ★★★★★ (Based on Reviews and 17 reference(s) in Google Scholar.)

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