(32-Carbonyl)-RMC-5552 |
| رقم الكتالوجGC63524 |
(32-Carbonyl) -RMC-5552 هو مثبط قوي لـ mTOR(32-Carbonyl) -RMC-5552 يثبط mTORC1 و mTORC2 الركيزة (p-P70S6K- (T389) ، p-4E-BP1- (T37 / 36) ، AND p-AKT1 / 2 / 3- (S473)) الفسفرة باستخدام pIC50s من> 9 ،> 9 وبين 8 و 9 على التوالي (براءة اختراع WO2019212990A1 ، المثال 2)
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Cas No.: 2382768-55-8
Sample solution is provided at 25 µL, 10mM.
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(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2)[1].
[1]. Jennifer PITZEN, et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1.
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