Abemaciclib metabolite M18 hydrochloride (Synonyms: LSN3106729 hydrochloride) |
| رقم الكتالوجGC63728 |
مستقلب Abemaciclib M18 (LSN3106729) هيدروكلوريد ، مستقلب Abemaciclib ، هو مثبط CDK مع نشاط مضاد للأورامتم استخدام مستقلب Abemaciclib M18 هيدروكلوريد ورابط CRBN لتصميم ديجريدر PROTAC CDK4 / 6
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Sample solution is provided at 25 µL, 10mM.
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Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1].
[1]. Edward S. Kim, et al. Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non-Small Cell Lung Cancer: A Phase Ib Study.
[2]. Nathanael Gray, et al. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use. WO2017185031A1.
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