Abemaciclib metabolite M18 hydrochloride (Synonyms: LSN3106729 hydrochloride) |
Catalog No.GC63728 |
Le chlorhydrate du métabolite M18 (LSN3106729) d'Abemaciclib, le métabolite de l'Abemaciclib, est un inhibiteur de CDK avec une activité antitumorale. Le chlorhydrate du métabolite M18 de l'abémaciclib et un ligand CRBN ont été utilisés pour concevoir le dégradeur PROTAC CDK4/6.
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Sample solution is provided at 25 µL, 10mM.
Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1].
[1]. Edward S. Kim, et al. Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non-Small Cell Lung Cancer: A Phase Ib Study.
[2]. Nathanael Gray, et al. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use. WO2017185031A1.
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