ABO (hydrochloride) |
| رقم الكتالوجGC42677 |
ABO is a modulator of annexin A7.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2309172-24-3
Sample solution is provided at 25 µL, 10mM.
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ABO is a modulator of annexin A7. It binds to Thr286 and inhibits phosphorylation of annexin A7 at threonine, but not serine or tyrosine, residues in human umbilical vein endothelial cells (HUVECs). ABO enhances the interaction between annexin A7 and the EF-hand protein GCA, decreases GCA phosphorylation as well as intracellular calcium concentration, and promotes autophagy in COS-7 cells. It also decreases phosphorylation of microtubule-associated protein 1 light chain (LC3) in HUVECs and suppresses oxidized low-density lipoprotein-induced increases in phosphatidylcholine-specific phospholipase C (PC-PLC) expression in vascular endothelial cells (VECs). In vivo, ABO (50 or 100 mg/kg per day) decreases PC-PLC levels, enhances autophagy, and reduces apoptosis, lipid deposition, and atherosclerotic plaque area in the aortic endothelium of apoE-/- mice fed a Western diet.
| Cas No. | 2309172-24-3 | SDF | |
| Canonical SMILES | NC1=CC=C(OCC(CO)N2)C2=C1.Cl.Cl | ||
| Formula | C9H12N2O2•2HCl | M.Wt | 253.1 |
| الذوبان | DMF: 2 mg/ml,DMSO: 2 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 5 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.951 mL | 19.755 mL | 39.5101 mL |
| 5 mM | 0.7902 mL | 3.951 mL | 7.902 mL |
| 10 mM | 0.3951 mL | 1.9755 mL | 3.951 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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