PIM-447 dihydrochloride (Synonyms: LGH447 dihydrochloride) |
| رقم الكتالوجGC36918 |
ثنائي هيدروكلوريد PIM447 (LGH447 ثنائي هيدروكلوريد) هو مثبط قوي ، ومتوفر عن طريق الفم ، وانتقائي كيناز بان-بيم ، بقيم Ki تبلغ 6 و 18 و 9 مساءً لـ PIM1 و PIM2 و PIM3 ، على التوالييعرض ثنائي هيدروكلوريد PIM447 تأثيرات مزدوجة مضادة للورم النخاعي وتأثيرات واقية للعظامثنائي هيدروكلوريد PIM447 يحث على موت الخلايا المبرمج
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1820565-69-2
Sample solution is provided at 25 µL, 10mM.
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PIM447 is a pan-PIM kinase ihibitor with Kis of 6, 18, 9 nM for PIM1, PIM2 and PIM3, respectively.
[1]. PaÍno T et al. The novel pan-PIM kinase inhibitor, PIM447, displays dual anti-myeloma and bone protective effects, and potently synergizes with current standards of care. Clin Cancer Res. 2016 Jul 20. [2]. Burger MT et al. Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies. J Med Chem. 2015 Nov 12;58(21):8373-86. [3]. Peters TL et al. Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.Oncotarget. 2016 Aug 20
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