ABT-670 |
| カタログ番号GC33552 |
ABT-670 はドーパミン D4 受容体の選択的経口生物学的利用能アゴニストであり、EC50 はそれぞれヒト D4、フェレット D4、およびラット D4 に対して 89 nM、160 nM、および 93 nM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 630119-43-6
Sample solution is provided at 25 µL, 10mM.
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ABT-670 is a selective, oral bioavailable agonist of dopamine D4 receptor, with EC50 of 89 nM, 160 nM, and 93 nM for human D4, ferret D4, and rat D4, respectively.
ABT-670 is a selective D4 agonist, with EC50 of 89 nM, 160 nM, and 93 nM for human D4, ferret D4, and rat D4, respectively[1].
ABT-670 (0.1 μmol/kg) robustly induces a high (75%) incidence of erections in male rats. ABT-670 exhibits excellent oral bioavailability in rat, dog, and monkey (68%, 85%, and 91%, respectively) with comparable efficacy, safety, and tolerability[1].
[1]. Patel MV, et al. Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. J Med Chem. 2006 Dec 14;49(25):7450-65.
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