Acid-PEG3-C2-Boc |
| رقم الكتالوجGC60561 |
Acid-PEG3-C2-Boc عبارة عن رابط PROTAC قائم على PEG و Alkyl / ether يمكن استخدامه في تخليق PROTACs لتدهور EGFR وتثبيط mTOR
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Cas No.: 1807539-06-5
Sample solution is provided at 25 µL, 10mM.
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Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1. [2]. Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1.
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