ACT 462206 |
| رقم الكتالوجGC50142 |
ACT 462206 هو مضاد لمستقبلات Orexin 1 / Orexin 2 ثنائي النشط عن طريق الفم وفعال مع IC50s من 60 نانومتر (Orexin 1) و 11 نانومتر (Orexin 2) ، على التوالي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1361321-96-1
Sample solution is provided at 25 µL, 10mM.
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Potent, dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively). Exhibits anxiolytic-like properties in vivo. Brain penetrant.
Boss et al (2014) Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. ChemMedChem. 9 2486 PMID:25147058
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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