ACT 462206 |
| Catalog No.GC50142 |
ACT 462206 est un antagoniste double des récepteurs Orexin 1/Orexin 2 actif par voie orale et puissant avec des IC50 de 60 nM (Orexin 1) et 11 nM (Orexin 2), respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1361321-96-1
Sample solution is provided at 25 µL, 10mM.
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Potent, dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively). Exhibits anxiolytic-like properties in vivo. Brain penetrant.
Boss et al (2014) Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. ChemMedChem. 9 2486 PMID:25147058
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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