الصفحة الرئيسية>>Signaling Pathways>> PI3K/Akt/mTOR Signaling>> Akt>>AKT Kinase Inhibitor

AKT Kinase Inhibitor

رقم الكتالوجGC16366

مثبط AKT Kinase هو مثبط لإنزيم أكت كيناز يحتوي على نشاط مضاد للأورام.

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AKT Kinase Inhibitor التركيب الكيميائي

Cas No.: 842148-40-7

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
347٫00
متوفر
5mg
315٫00
متوفر
10mg
540٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com

مراجعات العميل

بناء على آراء العملاء.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].

The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion[1].

Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus[1].

References:
[1]. Saverio Alberti, et al. Use of trop-2 as predictive marker of response to anti-tumor therapy based on inhibitors of cd9, akt and molecules of the tetraspanin signalling network. WO2013171777A2.

مراجعات

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