Arachidonoyl Cyclopropylamide (Synonyms: ACPA) |
| カタログ番号GC18615 |
アラキドノイルシクロプロピルアミド（ACPA）は、CB1受容体に対してKi値が2.2、CB2受容体に対して715 nMの強力で選択的なカンナビノイド（CB）受容体1作動薬です。
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Cas No.: 229021-64-1
Sample solution is provided at 25 µL, 10mM.
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Arachidonoyl cyclopropylamide (ACPA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 2.2 and 715 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACPA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide , in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.
References:
[1].Pertwee, R.G. Pharmacology of cannabinoid receptor ligands Curr. Med. Chem. 6(8), 635-664 (1999).
[2]. Hillard, C.J., Manna, S., Greenberg, M.J., et al. Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1) J. Pharmacol. Exp. Ther. 289(3), 1427-1433 (1999).
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