AS-85 |
| رقم الكتالوجGC65918 |
AS-85 هو مثبط قوي للهيستون ميثيل ترانسفيراز ASH1L (IC50 = 0.6 μ ؛ M) مع نشاط مضاد لسرطان الدم. يرتبط AS-85 بقوة بمجال ASH1L SET ، بقيمة Kd تبلغ 0.78μ ؛ M.
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Cas No.: 2323623-80-7
Sample solution is provided at 25 µL, 10mM.
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AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC50=0.6 µM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the Kd value of 0.78 µM[1].
AS-85 inhibits the growth of leukemia cells (MV4;11, MOLM13, and KOPN8) harboring different MLL1 translocations, with GI50 values ranging from 5 µM to 25 µM, and demonstrates no effect in K562 leukemia cells without MLL1 translocations[1].
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