AS-85 |
| Catalog No.GC65918 |
AS-85는 항백혈병 활성이 있는 강력한 ASH1L 히스톤 메틸트랜스퍼라제 억제제(IC50=0.6 μM)입니다. 821d96072c2d58d8970e76f526b0f6b8AS-85는 Kd 값이 0.78μM인 ASH1L SET 도메인에 강력하게 결합합니다.821d96072c2d58d8970e76f526b0f6b8
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Cas No.: 2323623-80-7
Sample solution is provided at 25 µL, 10mM.
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AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC50=0.6 µM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the Kd value of 0.78 µM[1].
AS-85 inhibits the growth of leukemia cells (MV4;11, MOLM13, and KOPN8) harboring different MLL1 translocations, with GI50 values ranging from 5 µM to 25 µM, and demonstrates no effect in K562 leukemia cells without MLL1 translocations[1].
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