Asundexian (Synonyms: BAY-2433334) |
| رقم الكتالوجGC65912 |
Asundexian (BAY 2433334) هو أحد مثبطات عامل التخثر النشط عن طريق الفم Xia (FXIa). يرتبط Asundexian بشكل مباشر وفعال وقابل للعكس بالموقع النشط لـ FXIa وبالتالي يمنع نشاطه. يمنع Asundexian العامل FXIa البشري في المخزن المؤقت باستخدام IC50 من 1 نانومتر.
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Cas No.: 2064121-65-7
Sample solution is provided at 25 µL, 10mM.
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Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM[1].
Asundexian displays potent anticoagulant activity in vitro in human and rabbit plasma and antithrombotic efficacy in vivo in a rabbit arterial thrombosis model[1].
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