Asundexian (Synonyms: BAY-2433334) |
| Katalog-Nr.GC65912 |
Asundexian (BAY 2433334) ist ein oral aktiver Hemmer des Gerinnungsfaktors Xia (FXIa). Asundexian bindet direkt, stark und reversibel an das aktive Zentrum von FXIa und hemmt dadurch dessen AktivitÄt. Asundexian hemmt humanes FXIa in Puffer mit einem IC50 von 1 nM.
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Cas No.: 2064121-65-7
Sample solution is provided at 25 µL, 10mM.
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Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM[1].
Asundexian displays potent anticoagulant activity in vitro in human and rabbit plasma and antithrombotic efficacy in vivo in a rabbit arterial thrombosis model[1].
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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