Asundexian (Synonyms: BAY-2433334) |
| Catalog No.GC65912 |
Asundexian (BAY 2433334) est un inhibiteur du facteur de coagulation Xia (FXIa) actif par voie orale. L'asundexian se lie directement, puissamment et de manière réversible au site actif du FXIa et inhibe ainsi son activité. Asundexian inhibe le FXIa humain dans un tampon avec une IC50 de 1 nM.
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Cas No.: 2064121-65-7
Sample solution is provided at 25 µL, 10mM.
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Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM[1].
Asundexian displays potent anticoagulant activity in vitro in human and rabbit plasma and antithrombotic efficacy in vivo in a rabbit arterial thrombosis model[1].
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