Atabecestat (Synonyms: JNJ-54861911) |
| رقم الكتالوجGC39341 |
Atabecestat (JNJ-54861911) هو مخترق قوي للدماغ ونشط فموياً في موقع سلائف بروتين الأميلويد مثبط إنزيم 1 (BACE1) ، ويحقق انخفاضًا قويًا وعاليًا في CSF Aβ
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Cas No.: 1200493-78-2
Sample solution is provided at 25 µL, 10mM.
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Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction. Atabecestat (JNJ-54861911) is tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].
[1]. Timmers M, et al. Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor.Alzheimers Dement (N Y). 2016 Aug 24;2(3):202-212.
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