Atabecestat (Synonyms: JNJ-54861911) |
Catalog No.GC39341 |
L'atabecestat (JNJ-54861911) est un puissant inhibiteur de l'enzyme de clivage de la protéine précurseur de l'amyloÏde 1 (BACE1) pénétrant dans le cerveau et actif par voie orale, qui permet une réduction robuste et élevée de l'Aβ dans le LCR.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1200493-78-2
Sample solution is provided at 25 µL, 10mM.
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction. Atabecestat (JNJ-54861911) is tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].
[1]. Timmers M, et al. Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor.Alzheimers Dement (N Y). 2016 Aug 24;2(3):202-212.
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