AZD1390 |
| رقم الكتالوجGC19468 |
AZD1390 هو مثبط قوي وانتقائي لـ ATM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2089288-03-7
Sample solution is provided at 25 µL, 10mM.
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AZD1390 is a potent and selective ATM inhibitor with the ability to cross the blood-brain barrier suitable for the treatment of intracranial malignancies.AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50 = 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases.
AZD1390 displays excellent oral bioavailability in preclinical species (66% in rat and 74% in dog), is not a substrate for human efflux transporters, and has been shown to efficiently cross the BBB in non-human primate PET studies.
Reference:
http://mct.aacrjournals.org/content/17/1_Supplement/A124
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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