AZD2423 |
| رقم الكتالوجGC60615 |
AZD2423 عبارة عن مُعدِّل خيفي سلبي لمستقبلات CCR2 الكيميائي قوي ، وانتقائي ، ومتوفر بيولوجيًا عن طريق الفم ، وغير تنافسي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1229603-37-5
Sample solution is provided at 25 µL, 10mM.
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AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca2+ flux [1][2][3].
AZD2423 inhibits MCP-1 induced calcium mobilization and chemotaxis of THP-1 cell line with an IC50 of 4 nM[1].
[1]. AZD2423. [2]. John G. Cumming. CCR2 antagonists for the treatment of neuropathic pain: The discovery and development of AZD2423. [3]. KalliomÄki J, et al. A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia. Pain. 2013 May;154(5):761-7.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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