AZD4320 |
| رقم الكتالوجGC33255 |
AZD4320 عبارة عن مثبط ثنائي BCL2 / BCLxL جديد يحاكي BH3 مع IC50s من 26 نانومتر و 17 نانومتر و 170 نانومتر لخلايا KPUM-MS3 و KPUM-UH1 و STR-428 ، على التوالي
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Cas No.: 1357576-48-7
Sample solution is provided at 25 µL, 10mM.
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AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively.
AZD4320 potently augments the antitumor effect of AZD5153 in double expressing lymphoma (DEL)- and double hit lymphoma (DHL)-derived cell lines in a dose-dependent manner. AZD4320 shows mostly synergistic, and at least additive, growth inhibitory effects on DEL- and DHL derived cell lines, and profoundly increases cells undergoing apoptosis in all three cell lines[1].
[1]. Takimoto-Shimomura T, et al. Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2. Invest New Drugs. 2018 Jun 21.
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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