Belizatinib (Synonyms: TSR-011) |
| رقم الكتالوجGC19063 |
بيليزاتينيب هو مثبط شفوي ، مزدوج ، قوي لـ ALK و TRKA و TRKB و TRKC ، مع IC50 من 0.7 نانومتر من أجل ALK كيناز المؤتلف من النوع البري
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Cas No.: 1357920-84-3
Sample solution is provided at 25 µL, 10mM.
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Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.
TSR-011 has antitumour activity in the clinical trials.
TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models[1].
References:
[1]. Sullivan I, et al. ALK inhibitors in non-small cell lung cancer: the latest evidence and developments. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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