Bis(methylthio)gliotoxin (Synonyms: Bisdethiobis(methylthio)gliotoxin, FR 49175) |
رقم الكتالوجGC42941 |
يعتبر السم الجليوتوكسين ثنائي (ميثيلثيو) علامة أكثر استقرارًا وموثوقية لداء الرشاشيات الغازية من السم الجليوتوكسين ومناسب للاستخدام في التشخيص
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Cas No.: 74149-38-5
Sample solution is provided at 25 µL, 10mM.
Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 µM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC50s = >400 µM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 µM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD50 = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.
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