Bis(methylthio)gliotoxin (Synonyms: Bisdethiobis(methylthio)gliotoxin, FR 49175) |
| Catalog No.GC42941 |
La bis(méthylthio)gliotoxine est un marqueur plus stable et plus fiable de l'aspergillose invasive que la gliotoxine et convient pour une utilisation dans le diagnostic.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 74149-38-5
Sample solution is provided at 25 µL, 10mM.
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Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 µM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC50s = >400 µM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 µM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD50 = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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