Bis(methylthio)gliotoxin (Synonyms: Bisdethiobis(methylthio)gliotoxin, FR 49175) |
| Catalog No.GC42941 |
비스(메틸티오)글리오톡신은 글리오톡신보다 침습성 아스페르길루스증에 대한 더 안정적이고 신뢰할 수 있는 마커이며 진단에 사용하기에 적합합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 74149-38-5
Sample solution is provided at 25 µL, 10mM.
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Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 µM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC50s = >400 µM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 µM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD50 = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.
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