BM-1244 (Synonyms: APG-1252-M1) |
| رقم الكتالوجGC62871 |
BM-1244 (APG-1252-M1) هو مثبط قوي Bcl-xL / Bcl-2 مع Kis من 134 و 450 نانومتر لـ Bcl- xL و Bcl-2 ، على التواليBM-1244 يثبط الخلايا الليفية الشائخة (SnCs) مع EC50 من 5 نانومتر(من براءة الاختراع WO2019033119A1)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1619923-32-8
Sample solution is provided at 25 µL, 10mM.
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BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (From patent WO2019033119A1)[1].
[1]. Jill Hopkins, et al. Treatment of ophthalmic conditions such as macular degeneration, glaucoma, and diabetic retinopathy using pharmaceutical agents that eliminate senescent cells. WO2019033119A1.
[2]. Kim R. Unknotting the roles of Bcl-2 and Bcl-xL in cell death. Biochem Biophys Res Commun. 2005;333(2):336-343.
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