BM-1244 (Synonyms: APG-1252-M1) |
| Catalog No.GC62871 |
BM-1244 (APG-1252-M1) est un puissant inhibiteur de Bcl-xL/Bcl-2 avec un Kis de 134 et 450 nM pour Bcl-xL et Bcl-2, respectivement. BM-1244 inhibe les fibroblastes sénescents (SnCs) avec une CE50 de 5 nM. (D'après le brevet WO2019033119A1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1619923-32-8
Sample solution is provided at 25 µL, 10mM.
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BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (From patent WO2019033119A1)[1].
[1]. Jill Hopkins, et al. Treatment of ophthalmic conditions such as macular degeneration, glaucoma, and diabetic retinopathy using pharmaceutical agents that eliminate senescent cells. WO2019033119A1.
[2]. Kim R. Unknotting the roles of Bcl-2 and Bcl-xL in cell death. Biochem Biophys Res Commun. 2005;333(2):336-343.
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