BMS 795311 |
| رقم الكتالوجGC50257 |
BMS 795311 هو مثبط قوي ومتوفر بيولوجيًا عن طريق الفم لبروتين نقل إستر الكوليستريل (CETP) ، مع IC50s من 4 نانومتر في اختبار القرب التألق القائم على الإنزيم (SPA) و 0.22 ميكرومتر في فحص البلازما البشري الكامل (hWPA) ، على التوالي.
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Cas No.: 939390-99-5
Sample solution is provided at 25 µL, 10mM.
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Potent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay). Inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Orally bioavailable.
Qiao et al (2015) Triphenylethanamine derivatives as cholesteryl ester transfer protein inhibitors: discovery of N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamid J.Med.Chem. 58 9010 PMID:26524347
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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