BMS 795311 |
| Catalog No.GC50257 |
Le BMS 795311 est un inhibiteur puissant et biodisponible par voie orale de la protéine de transfert des esters de cholestérol (CETP), avec des IC50 de 4 nM dans un test de proximité par scintillation (SPA) à base d'enzymes et de 0,22 μM dans un test sur plasma entier humain (hWPA), respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 939390-99-5
Sample solution is provided at 25 µL, 10mM.
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Potent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay). Inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Orally bioavailable.
Qiao et al (2015) Triphenylethanamine derivatives as cholesteryl ester transfer protein inhibitors: discovery of N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamid J.Med.Chem. 58 9010 PMID:26524347
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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