الصفحة الرئيسية>>Signaling Pathways>> DNA Damage/DNA Repair>> DNA/RNA Synthesis>>BRACO 19 trihydrochloride

BRACO 19 trihydrochloride

رقم الكتالوجGC50140

BRACO 19 ثلاثي هيدروكلوريد هو مثبط قوي للإنزيم تيلوميراز / التيلومير ، مما يمنع عمل السد والتحفيز للإنزيم تيلوميراز.

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BRACO 19 trihydrochloride التركيب الكيميائي

Cas No.: 1177798-88-7

الحجم السعر المخزون الكميّة
10 mg
316٫00
متوفر
50 mg
1327٫00
متوفر

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مراجعات العميل

بناء على آراء العملاء.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

Telomerase inhibitor (IC50 = 115 nM). Inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro. Inhibits growth of uterine tumor xenografts in mice.

Gowan et al (2002) A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol.Pharmacol. 61 1154 PMID:11961134 |Burger et al (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res. 15 1489 PMID:15735037

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