C-1 |
| رقم الكتالوجGC11605 |
C-1 هو مثبط كيناز قوي للبروتين ، مع IC50s من 4 μ ؛ M ، 8 μ ؛ M ، 12 μ ؛ M و 240 μ ؛ M لبروتين كيناز المعتمد على cGMP (PKG) ، بروتين كيناز المعتمد على cAMP (PKA) وبروتين كيناز C (PKC) و MLC-kinase على التوالي. يستخدم C-1 أيضًا كمثبط ROCK.
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Cas No.: 84468-24-6
Sample solution is provided at 25 µL, 10mM.
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HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase with IC50s of 4, 8, 12 and 240 μM, respectively[1].
HA-100 inhibits MLC-kinase and PKC competitively with respect to ATP, and the Ki values are 61 and 6.5 μM, respectively[1].
References:
[1]. Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.
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