Ca2+ channel agonist 1 |
| رقم الكتالوجGC30977 |
ناهض قناة Ca2 + 1 هو ناهض لقناة N-type Ca2 + ومثبط لـ Cdk2 ، مع EC50s من 14.23 ميكرومتر و 3.34 ميكرومتر ، على التوالي ، ويستخدم كعلاج محتمل لخلل وظيفي في العصب الحركي
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Cas No.: 1402821-24-2
Sample solution is provided at 25 µL, 10mM.
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Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.
Ca2+ channel agonist 1 (Compound 13d) is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively. Ca2+ channel agonist 1 exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine[1].
[1]. Liang M, et al. Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist. ACS Med Chem Lett. 2012 Oct 1;3(12):985-990.
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