Carbosulfan |
| رقم الكتالوجGC32257 |
مثبط الكاربوسلفان CYP3A4 بشكل قوي نسبيًا و CYP1A1 / 2 و CYP2C19 بشكل معتدل في HLM المجمعة (الكبد البشري)
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Cas No.: 55285-14-8
Sample solution is provided at 25 µL, 10mM.
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Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan activation is predominantly catalyzed in humans by CYP3A4.
[1]. Abass K, et al. Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved. Chem Biol Interact. 2010 May 14;185(3):163-173.
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