Rac-VU 6008667 |
| رقم الكتالوجGC38111 |
Rac-VU 6008667 هو مُعدِّل خيفي انتقائي سلبي من النوع الفرعي لمستقبلات الأسيتيل كولين المسكارينية 5 (M5 NAM) (IC50 \u003d 1.8 ميكرومتر ، pIC50 \u003d 5.75) ، لديه اختراق عالي للجهاز العصبي المركزي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2092917-63-8
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Rac-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. Rac-VU 6008667 has high CNS penetration[1]. M5 NAM: muscarinic acetylcholine receptor subtype 5.
[1]. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *