UK-371804 |
| رقم الكتالوجGC31716 |
UK-371804 عبارة عن مثبط منشط البلازمينوجين من نوع urokinase (uPA) مع Ki يبلغ 10 نانومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 256477-09-5
Sample solution is provided at 25 µL, 10mM.
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UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.
UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 μM). UK-371804 has its excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin)[1].
In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM[1].
[1]. Fish PV, et al. Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51.
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