V-9302 hydrochloride |
| رقم الكتالوجGC39253 |
في-9302 هيدروكلورايد هو خصم تنافسي لتدفق الجلوتامين عبر الغشاء الخلوي. يستهدف في-9302 هيدروكلورايد بشكل انتقائي وبقوة ناقل حمض أمين SLC1A5 (ASCT2) ولا يستهدف ASCT1. يثبط في-9302 هيدروكلورايد امتصاص الجلوتامين المحفز بـ ASCT2 (IC50 = 9.6 ميلِّمولار) في خلاية HEK-293.
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Cas No.: 2416138-42-4
Sample solution is provided at 25 µL, 10mM.
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V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. V-9302 hydrochloride selectively and potently targets the amino acid transporter ASCT2 (SLC1A5). V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake (IC50=9.6 µM) in HEK-293 cells[1].
[1]. Schulte ML, et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacyin preclinical models. Nat Med. 2018 Feb;24(2):194-202.
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