V-9302 hydrochloride |
| Catalog No.GC39253 |
El clorhidrato de V-9302 es un antagonista competitivo del flujo transmembrana de glutamina. El clorhidrato de V-9302 se dirige selectiva y potente al transportador de aminoácidos ASCT2 (SLC1A5), no a ASCT1. El clorhidrato de V-9302 inhibe la captación de glutamina mediada por ASCT2 (IC50=9,6 uM) en células HEK-293.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2416138-42-4
Sample solution is provided at 25 µL, 10mM.
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V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. V-9302 hydrochloride selectively and potently targets the amino acid transporter ASCT2 (SLC1A5). V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake (IC50=9.6 µM) in HEK-293 cells[1].
[1]. Schulte ML, et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacyin preclinical models. Nat Med. 2018 Feb;24(2):194-202.
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