V-9302 hydrochloride |
| カタログ番号GC39253 |
V-9302塩酸塩は、膜貫通型グルタミンフラックスの競合的拮抗剤です。V-9302塩酸塩は、アミノ酸トランスポーターASCT2（SLC1A5）に選択的かつ強力に作用し、ASCT1には作用しません。V-9302塩酸塩は、HEK-293細胞でASCT2介在のグルタミン取り込みを阻害します（IC50=9.6μM）。
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Cas No.: 2416138-42-4
Sample solution is provided at 25 µL, 10mM.
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V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. V-9302 hydrochloride selectively and potently targets the amino acid transporter ASCT2 (SLC1A5). V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake (IC50=9.6 µM) in HEK-293 cells[1].
[1]. Schulte ML, et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacyin preclinical models. Nat Med. 2018 Feb;24(2):194-202.
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