الصفحة الرئيسية>>Signaling Pathways>> Others>>AP C5

AP C5

رقم الكتالوجGC50527

يعرض AP C5 تثبيطًا انتقائيًا لـ guanosine 3 ، 5′-cyclic monophosphate (cGMP) - بروتين كيناز II المعتمد (cGKII) مع pIC50 من 7.2 ، والذي يمكن استخدامه للبحث في أمراض الإسهال.

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AP C5 التركيب الكيميائي

Cas No.: 2234272-10-5

الحجم السعر المخزون الكميّة
5mg
60٫00
متوفر
10mg
106٫00
متوفر
50mg
347٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com

مراجعات العميل

بناء على آراء العملاء.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.

Bijvelds et al (2018) Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J.Biol.Chem. 293 8173 PMID:29653944

مراجعات

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