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AP C5

カタログ番号GC50527

AP C5 は、グアノシン 3',5'-環状一リン酸 (cGMP) 依存性プロテインキナーゼ II (cGKII) の選択的阻害を pIC50 7.2 で示し、下痢性疾患の研究に使用できます。

Products are for research use only. Not for human use. We do not sell to patients.

AP C5 化学構造

Cas No.: 2234272-10-5

サイズ 価格 在庫数 個数
5mg
$60.00
在庫あり
10mg
$106.00
在庫あり
50mg
$347.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.

Bijvelds et al (2018) Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J.Biol.Chem. 293 8173 PMID:29653944

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Average Rating: 5 ★★★★★ (Based on Reviews and 7 reference(s) in Google Scholar.)

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